A live birth of activated one-day-old unfertilized oocyte for a patient who experienced repeatedly near-total fertilization failure after intracytoplasmic sperm injection / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 546-548, 2012.
Article
in English
| WPRIM
| ID: wpr-262573
ABSTRACT
Total or near-total fertilization failure after intracytoplasmic sperm injection (ICSI) is a rare event, but it occurs repeatedly because of sperm defects in activating oocyte. The case presents a successful pregnancy and live birth after calcium ionophore A23187 (A23187) activation on one-day-old unfertilized oocytes in a patient whose husband suffered oligoasthenoteratozoospermia, and who had experienced repeated near-total fertilization failure after ICSI. In the second ICSI cycle, only one oocyte was fertilized while nine were unfertilized. Oocyte activation with A23187 were performed on the one-day-old unfertilized oocytes after ICSI and resulted in fertilization and embryo transfer. A clinical pregnancy was achieved and a healthy baby was born. To our knowledge, this is the first reported case of a healthy birth after oocyte activation on the one-day-old unfertilized oocyte. This indicates that "rescue oocyte activation" on one-day-old unfertilized oocytes after ICSI may be helpful for preventing total or near-total fertilization failure after ICSI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oocytes
/
Fertilization in Vitro
/
Sperm Injections, Intracytoplasmic
/
Cell Biology
/
Live Birth
/
Methods
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
English
Journal:
Chinese Medical Journal
Year:
2012
Type:
Article
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