The research on the correlation between eotaxin-3 gene polymorphisms and allergic asthma / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 169-172, 2006.
Article
in Zh
| WPRIM
| ID: wpr-263827
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study in the linkage between eotaxin-3 gene polymorphisms and allergic asthma susceptivity, blood plasma IgE or peripheral blood eosinophil in adult population of Han nationality from Hubei province of China.</p><p><b>METHODS</b>Polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP), tetra-primer PCR technique and restriction analysis were applied to identify the single nucleotide polymorphism.</p><p><b>RESULTS</b>The allele frequency of eotaxin-3 +2497 G, total levels of plasma IgE and peripheral blood eosinophil counts revealed the significant difference between control and allergic asthma group, that the P value was 0.011, 0.021 or 0.029 respectively. The allele frequency of eotaxin-3 +77 T and total levels of plasma IgE showed to have no significant difference between control and allergic asthma group, that the P value was 0.824 and 0.473 respectively. However, the peripheral blood eosinophil counts was significantly different between control and allergic asthma group, and the P value was 0.044.</p><p><b>CONCLUSION</b>Single nucleotide polymorphism of eotaxin-3 +2497 is associated with the asthma susceptibility, peripheral eosinophil counts and total levels of plasma IgE in adult population from Hubei province, and polymorphism of +77 is associated with peripheral eosinophil counts.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Asthma
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Blood
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Immunoglobulin E
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DNA Mutational Analysis
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Molecular Sequence Data
/
Base Sequence
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China
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Chemokines, CC
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Genetic Predisposition to Disease
Limits:
Adult
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Female
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Humans
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Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2006
Type:
Article