Experimental study on combination attenuation of mutual-detoxication and mutual restraint about Aconiti Carmichaeli Radix / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2215-2218, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-263955
ABSTRACT
<p><b>OBJECTIVE</b>According to the record of mutual-detoxication and mutual restraint in ancient Chinese materia medica, to research the influence to the toxicity of Aconiti Carmichaeli Radix added the traditional Chinese medicine (TCM) which is mutual-detoxication and mutual restraint to it.</p><p><b>METHOD</b>ICR mouse, 0.4 microL x g(-1), to pour the fluid into stomach, paired comparison of acute toxicity of Aconiti Carmichaeli Radix seperately added different ratio of Sileris Radix, Astragali Radix and Polygalae Radix, and ad-measure the dose for LD50. SD rats, administration by injection through duodenum, 20 microL x g(-1), paired comparison of heart toxicity of Aconiti Carmichaeli Radix seperately added different ratio of Sileris Radix, Astragali Radix and Polygalae Radix, and admeasure the dose for TD50.</p><p><b>RESULT</b>LD50, and heart toxicity of TD50 were increased after Aconiti Carmichaeli Radix added separately, its toxicity attenuation is related to the ratio.</p><p><b>CONCLUSION</b>Mutual-detoxication and mutual restraint are the summary drawed when China ancient people is in the process of using toxic TCM and it is scientific.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Inactivation, Metabolic
/
Chemistry
/
Rats, Sprague-Dawley
/
Astragalus Plant
/
Polygala
/
Aconitum
/
Drug Compounding
/
Drug Interactions
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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