Protective effects of shikonin on brain injury induced by carbon ion beam irradiation in mice / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 148-151, 2015.
Article
in En
| WPRIM
| ID: wpr-264607
Responsible library:
WPRO
ABSTRACT
Radiation encephalopathy is the main complication of cranial radiotherapy. It can cause necrosis of brain tissue and cognitive dysfunction. Our previous work had proved that a natural antioxidant shikonin possessed protective effect on cerebral ischemic injury. Here we investigated the effects of shikonin on carbon ion beam induced radiation brain injury in mice. Pretreatment with shikonin significantly increased the SOD and CAT activities and the ratio of GSH/GSSG in mouse brain tissues compared with irradiated group (P<0.01), while obviously reduced the MDA and PCO contents and the ROS levels derived from of the brain mitochondria. The shikonin also noticeably improved the spatial memory deficits caused by carbon ion beam irradiation. All results demonstrated that shikonin could improve the irradiated brain injury which might resulted from its modulation effects on the oxidative stress induced by the 12C6+ ion beam.
Full text:
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Index:
WPRIM
Main subject:
Pharmacology
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Radiation Injuries, Experimental
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Radiation-Protective Agents
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Superoxide Dismutase
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Brain Injuries
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Catalase
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Random Allocation
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Naphthoquinones
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Specific Pathogen-Free Organisms
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Protein Carbonylation
Limits:
Animals
Language:
En
Journal:
Biomedical and Environmental Sciences
Year:
2015
Type:
Article