Modulation of gamma-aminobutyric acid on painful sense in central nervous system of morphine-dependent rats / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 278-282, 2008.
Article
in En
| WPRIM
| ID: wpr-264666
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of gamma-aminobutyric acid (GABA) on the electric activities of pain-excited neurons (PEN) in nucleus accumbens (NAc) in central nervous system (CNS) of morphine-dependent rats.</p><p><b>METHODS</b>After GABA or the GABA(A)-receptor antagonist, bicuculline (Bic), was injected into cerebral ventricles or NAc, right sciatic nerve was stimulated by electrical pulses, which was considered as traumatic pain stimulation. Extracellular recordings methods were used to record the electric activities of PEN in NAc.</p><p><b>RESULTS</b>When GABA was injected into intracerebroventricle (ICV) as well as NAc, it could decrease the pain-evoked discharge frequency and prolong the latency of PEN. Bic could interdict the above effects of GABA on the electric activities of PEN.</p><p><b>CONCLUSION</b>Exogenous GABA might have an inhibitory effect on the central pain adjustment. Furthermore, GABA and GABA(A) receptor participate and mediate the traumatic information transmission process in CNS.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pain
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Pathology
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Pharmacology
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Physiology
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Reaction Time
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Time Factors
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Bicuculline
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Action Potentials
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Drug Administration Schedule
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Rats, Wistar
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Neuroscience Bulletin
Year:
2008
Type:
Article