Testicular dysgenesis syndrome: an update / 中华男科学杂志
National Journal of Andrology
; (12): 1113-1116, 2010.
Article
in Zh
| WPRIM
| ID: wpr-266226
Responsible library:
WPRO
ABSTRACT
Researches on the testicular dysgenesis syndrome (TDS) have flourished in the recent decade, and a widely accepted view on its pathogenesis is that environmental endocrine disrupting chemicals (EDCs) act on Leydig cells and/or testicular Sertoli cells, resulting in abnormal development of the testis and leading to the symptoms of TDS. Molecular biological studies suggest a correlation of TDS etiology with insulin-like factor 3 (INSL-3), androgen receptor (AR), P27kip, WT-1 and Müllerian inhibiting substance (MIS). This review focuses on the progress in current researches on the etiology and mechanism of TDS.
Full text:
1
Index:
WPRIM
Main subject:
Testicular Diseases
/
Testicular Neoplasms
/
Cryptorchidism
/
Genetics
/
Gonadal Dysgenesis
Limits:
Humans
/
Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2010
Type:
Article