NMR studies on cetirizine hydrochloride / 药学学报
Acta Pharmaceutica Sinica
; (12): 767-770, 2003.
Article
in Zh
| WPRIM
| ID: wpr-266607
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To study the NMR phenomena of cetirizine hydrochloride and assign all proton and carbon signals in NMR spectra.</p><p><b>METHODS</b>To record the 1D and 2D NMR spectra of cetirizine hydrochloride while changing the experimental temperature and adding D2O into the solution.</p><p><b>RESULTS</b>More than one NMR signal or broad peak resulting from piperazine and the attached groups with N atom were given in DMSO-d6 solution at room temperature. "Coalescence" or narrowing had occurred for the proton and carbon signals when the experimental temperature was increased or D2O was added into the solution.</p><p><b>CONCLUSION</b>Compared with the NMR "time scale", there are more than one conformation of cetirizine hydrochloride in DMSO-d6 solution at room temperature. The different conformation will be exchanged fast while temperature rise and the stable conformation will be existed while D2O was added into the solution.</p>
Full text:
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Index:
WPRIM
Main subject:
Protein Conformation
/
Temperature
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Chemistry
/
Cetirizine
/
Deuterium
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article