Synthesis of propenamides with anti-malarial activities and 3D-QSAR study / 药学学报

ABSTRACT

<p><b>AIM</b>To establish 3D QSAR model of propenamides with anti-malarial activities.</p><p><b>METHODS</b>Chemical synthesis combined with comparative molecular field analysis (CoMFA).</p><p><b>RESULTS</b>Generated QSAR models for activities of inhibiting chloroquine resistive malaria (W2) and chloroquine sensitive malaria (D6).</p><p><b>CONCLUSION</b>The activity of anti-W2 depends mostly on steric interaction and the activity of anti-D6 depends on both steric and electrostatic interaction.</p>