Outcomes of chemotherapy in patients with EGFR mutation-negative non-small cell lung cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 386-388, 2013.
Article
in Zh
| WPRIM
| ID: wpr-267534
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of chemotherapy for patients with EGFR (exon 19 and 21) mutation-negative non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>One hundred and forty NSCLC patients with negative EGFR mutation (90 cases) or EGFR mutation (50 cases) underwent gemcitabine or vinorelbine plus cisplatin or carboplatin chemotherapy.</p><p><b>RESULTS</b>In the EGFR mutation-negative patients, there were PR in 26 cases, SD in 48 cases, PD in 16 cases, the disease control rate was 82.2%. In the patients with EGFR mutation, there were PR in 14 cases, SD in 23 cases, PD in 13 cases, the disease control rate was 74.0%. The difference of disease control rates in the two groups was not significant (P = 0.250). The progression free survival (PFS) of EGFR mutation-negative patients was 4.2 months (95%CI 3.8-4.6) vs. 4.0 months (95%CI 3.6-4.4) in patients with EGFR mutation, with a significant difference (P = 0.021). The overall survival (OS) of EGFR mutation-negative patients was 9.2 months (95%CI 8.4-10.0) vs. 7.8 months (95%CI, 6.9-8.7) of patients with EGFR mutation (P = 0.028).</p><p><b>CONCLUSIONS</b>Chemotherapy can prolong the PFS and OS of EGFR mutation-negative patients. However, only the extension of OS has practical significance.</p>
Full text:
1
Index:
WPRIM
Main subject:
Vinblastine
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Remission Induction
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Antineoplastic Combined Chemotherapy Protocols
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Survival Rate
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Carboplatin
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Cisplatin
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Carcinoma, Non-Small-Cell Lung
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Disease-Free Survival
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Disease Progression
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Therapeutic Uses
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2013
Type:
Article