Expression of Rho-GDP dissociation inhibitor in the decidual tissues of preeclampsia patients and its clinical implication / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression of Rho-GDI in the decidual tissues of patients preeclampsia and explore its clinical implication.</p><p><b>METHODS</b>Real-time PCR, Western blotting and immunohistochemistry were used to detect the mRNA and protein expressions of Rho-GDI in the decidual tissues from 30 normal women with full-term pregnancy, 30 patients with early-onset severe preeclampsia and 30 with late-onset severe preeclampsia.</p><p><b>RESULTS</b>Rho-GDI expression was found mainly on the cell membrane and in the cytoplasm and nuclei of the decidual cells, occasionally occurring in the stroma. Both the mRNA and protein expressions of Rho-GDI in the decidual tissues were significantly higher in the normal pregnancy group than in the two severe preeclampsia groups (P<0.05), and the patients with late-onset severe preeclampsia had the lowest expressions of Rho-GDI.</p><p><b>CONCLUSION</b>The lowered expression of Rho-GDI in the deciduas might be involved in the pathogenesis and progression of preeclampsia.</p>