Preparation of tablets containing enteric-coated diclofenac sodium pellets / 药学学报
Acta Pharmaceutica Sinica
;
(12): 97-101, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-268164
ABSTRACT
Fluidized-bed manufactured enteric-coated diclofenac sodium pellets were compressed into tablets. The blend of two aqueous acrylic resins dispersion in different ratios, Eudragit NE30D and Eudragit L30D-55, were used to prepare enteric-coated diclofenac sodium pellets of different particle sizes and coating level. The cushioning pellets with different properties and these enteric-coated pellets were compressed into tablets in different proportions. The drug release of the tablets containing these pellets would be lower than 10% in 2 h in simulated gastric fluid, but reach (83 +/- 2.42)% in 1 h in simulated enteric fluid. The mixture of Eudragit NE30D and Eudragit L30D-55 could be used to prepare enteric pellets which are suitable for compression. The cushioning pellets which were composed of stearic acid/microcrystalline cellulose (41, w/w) could avoid rupture of the coating of pellets during the compression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Polymers
/
Solubility
/
Tablets, Enteric-Coated
/
Acrylic Resins
/
Drug Carriers
/
Cellulose
/
Chemistry
/
Anti-Inflammatory Agents, Non-Steroidal
/
Diclofenac
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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