Relationship of plasminogen activator inhibitor 1 gene 4G/5G polymorphisms to hypertension in Korean women / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1249-1253, 2012.
Article
in En
| WPRIM
| ID: wpr-269263
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Hypertension (HTN) is a major determinant of various cardiovascular events. Plasma levels of plasminogen activator inhibitor 1 (PAI-1) modulate this risk. A deletion/insertion polymorphism within the PAI-1 loci (4G/4G, 4G/5G, 5G/5G) affects the expression of this gene. The present study investigated the association between PAI-1 loci polymorphisms and HTN in Korean women.</p><p><b>METHODS</b>Korean women (n = 1312) were enrolled in this study to evaluate the association between PAI-1 4G/5G gene polymorphisms and HTN as well as other metabolic risk factors. PAI-1 loci polymorphisms were investigated using polymerase chain reaction amplification and single-strand conformation polymorphism analysis.</p><p><b>RESULTS</b>The three genotype groups differed with respect to systolic blood pressure (P = 0.043), and diastolic blood pressure (P = 0.009) but not with respect to age, body mass index, total cholesterol, low or high density lipoprotein cholesterol, triglycerides, or fasting blood glucose. Carriers of the PAI-1 4G allele had more hypertension significantly (PAI-1 4G/5G vs. PAI-1 5G/5G, P = 0.032; PAI-1 4G/4G vs. PAI-1 5G/5G, P = 0.034). When stratified according to PAI-1 4G/5G polymorphism, there was no significant difference in all metabolic parameters among PAI-1 genotype groups in patients with HTN as well as subjects with normal blood pressure. The estimated odds ratio of the 4G/4G genotype and 4G/5G for HTN was 1.7 (P = 0.005), and 1.6 (P = 0.015), respectively.</p><p><b>CONCLUSION</b>These findings might indicate that PAI-1 loci polymorphisms independently contribute to HTN and that gene-environmental interaction may be not associated in Korean women.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Plasminogen Activator Inhibitor 1
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Genetic Predisposition to Disease
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Asian People
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Genetics
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Genotype
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Hypertension
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
Language:
En
Journal:
Chinese Medical Journal
Year:
2012
Type:
Article