Glucocorticoid treatment for early postoperative cholangiole cholestasis hyperbilirubinemia after liver transplantation / 南方医科大学学报
Journal of Southern Medical University
; (12): 377-378, 2010.
Article
in Zh
| WPRIM
| ID: wpr-269545
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the therapeutic effect of glucocorticoid on early postoperative cholangiole cholestasis hyperbilirubinemia after liver transplantation.</p><p><b>METHODS</b>Thirteen liver transplantation recipients with serum total bilirubin above 171 micromol/L at two weeks to one month postoperatively were enrolled in this study. After exclusion of liver blood supply anomalies, bile duct complications, and acute rejection and establishment of a pathological diagnosis of cholangiole cholestasis by hepatic biopsy, hydrocortisone sodium succinate was infused. The liver functions of the patients were tested at 1 day before and 1 day and 1 week after the treatment. Hepatic biopsy was performed before and 1 week after the treatment to observe histopathological changes.</p><p><b>RESULTS</b>The serum levels of total bilirubin decreased significantly after the treatment with glucocorticoid. Pathology of the hepatic biopsy demonstrated the resolution of cholangiole cholestasis 1 week after the treatment.</p><p><b>CONCLUSION</b>Glucocorticoid treatment is effective for early postoperative cholangiole cholestasis hyperbilirubinemia after liver transplantation.</p>
Full text:
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Index:
WPRIM
Main subject:
Postoperative Complications
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Hydrocortisone
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Cholestasis, Intrahepatic
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Liver Transplantation
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Therapeutic Uses
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Drug Therapy
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Hyperbilirubinemia
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article