Plasma levels of D-dimer and von Willebrand factor and the therapeutic effect of compound glycyrrhizin in children with cytomegalovirus hepatitis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 272-274, 2010.
Article
in Zh
| WPRIM
| ID: wpr-270367
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the significance of plasma D-dimer and von Willebrand factor (vWF) and the therapeutic effect of compound glycyrrhizin in children with cytomegalovirus (CMV) hepatitis.</p><p><b>METHODS</b>Twenty healthy children, 16 asymptomatic cases with CMV infection and 52 cases of CMV hepatitis (21 cholestatic and 31 non-cholestatic) were enrolled. The 52 children with CMV hepatitis were randomly administered with conventional treatment alone or conventional treatment plus compound glycyrrhizin treatment. Plasma D-dimer and vWF levels were measured before and after treatment.</p><p><b>RESULTS</b>Plasma D-dimer and vWF levels in the CMV hepatitis group were markedly higher than those in the healthy control and asymptomatic CMV infection groups (P<0.01). The cholestatic hepatitis group had more increased plasma D-dimer and vWF levels compared with the non-cholestatic hepatitis group (P<0.01). Plasma D-dimer and vWF levels in the CMV hepatitis group were markedly reduced after conventional or compound glycyrrhizin treatment (P<0.01). Compound glycyrrhizin treatment decreased more significantly plasma D-dimer and vWF levels compared with the conventional treatment in children with CMV hepatitis (P<0.01).</p><p><b>CONCLUSIONS</b>The detection of plasma D-dimer and vWF is useful in the early assessment of liver damage in children with CMV hepatitis. Compound glycyrrhizin can decrease obviously plasma D-dimer and vWF levels and might thus provide protective effects against liver damage.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
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Blood
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Fibrin Fibrinogen Degradation Products
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Von Willebrand Factor
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Cytomegalovirus Infections
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Glycyrrhizic Acid
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Therapeutic Uses
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Drug Therapy
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Hepatitis, Viral, Human
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Liver Circulation
Limits:
Child, preschool
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Female
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Humans
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Infant
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Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2010
Type:
Article