Allergy-related evidences in relation to serum IgE: data from the China state key laboratory of respiratory disease, 2008-2013 / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 495-505, 2014.
Article
in En
| WPRIM
| ID: wpr-270573
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the serum total IgE (tIgE) and specific IgE (sIgE) to common allergens among allergic patients in Guangzhou, China.</p><p><b>METHODS</b>7 085 patients were examined for tIgE and sIgE to 15 allergens, based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.</p><p><b>RESULTS</b>3 758 (53.04%) patients tested positive for tIgE, and 4 640 (65.49%) for sIgE. Der pteronyssinus, Der farinae, eggs, and cow's milk were the most common allergens leading to higher positive rates of sIgE responses. Several peaks of sensitization were: Der pteronyssinus, Der farinae, and Blomia tropicalis at age 10-12; cow's milk at age below 3; eggs at age 4-6. The mean level and positive rate of tIgE tended to increase in subjects sensitized to more allergens. Sensitization to Der pteronyssinus (OR, 1.6; P<0.05), Der farinae (OR, 1.5; P<0.05), Blomia tropicalis (OR, 1.4; P<0.05), Blattella germanica (OR, 1.5; P<0.05), cow's milk (OR, 1.3; P<0.05), and soy beans (OR, 2.0; P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.</p><p><b>CONCLUSION</b>The major allergens in Guangzhou include Der pteronyssinus, Der farinae, cow's milk, and eggs. Sensitization to these allergens appears to be predictors of allergy-related disorder.</p>
Key words
Full text:
1
Index:
WPRIM
Main subject:
Respiratory Tract Diseases
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Blood
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Immunoglobulin E
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Allergens
/
Odds Ratio
/
China
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Epidemiology
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Retrospective Studies
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Allergy and Immunology
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Hypersensitivity
Type of study:
Etiology_studies
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Guideline
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Observational_studies
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Prognostic_studies
Limits:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Country/Region as subject:
Asia
Language:
En
Journal:
Biomedical and Environmental Sciences
Year:
2014
Type:
Article