Anticoagulant property of a semi-synthesized sodium beta-1,4-glucan sulfate / 药学学报
Acta Pharmaceutica Sinica
;
(12): 323-327, 2006.
Article
in English
| WPRIM
| ID: wpr-271434
ABSTRACT
<p><b>AIM</b>To investigate the anticoagulant efficacy and mechanism of a semi-synthesized sodium beta-1,4-glucan sulfate (Na-MCS).</p><p><b>METHODS</b>Anticoagulant activity was evaluated by means of coagulation assays in comparison with heparin. The anticoagulant mechanism of Na-MCS was disclosed by inhibitory analysis of the activities of coagulation factors using chromogenic substrates.</p><p><b>RESULTS</b>0.6 microg x mL(-1) Na-MCS could significantly prolong APTT and TT, but has less effect on PT at an even higher concentration. The dosage of Na-MCS required to double APTT of normal human plasma was 0.7 microg x mL(-1), lower than that of heparin with the activity of 150 u x mg(-1).</p><p><b>CONCLUSION</b>Na-MCS represented a potent anticoagulation activity in vitro, which matched the efficacy of heparin in a certain range of concentrations. Na-MCS exhibited anticoagulant activity due to inhibition of the coagulation factors IIa and Xa by the mediation of anti-thrombin AT-III.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Partial Thromboplastin Time
/
Pharmacology
/
Prothrombin Time
/
Thrombin Time
/
Blood Coagulation
/
Prothrombin
/
Heparin
/
Factor Xa
/
Antithrombin III
/
Dose-Response Relationship, Drug
Limits:
Humans
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS