Synthesis and vascular relaxing activity of arecoline derivatives coupled with nitric oxide donors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 71-75, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-271482
ABSTRACT
<p><b>AIM</b>To search for potential anti-atherosclerosis drugs with vascular relaxation activity, a series of agonists of endothelial targets were designed and synthesized.</p><p><b>METHODS</b>Coupling N-methyl-1,2, 3,6-tetrahydrapyridine ring system with 3,4-dibenzenesulfonyl-1,2,5-oxadiazole-2-oxide through esterification or amidation, a series of arecoline derivatives containing NO donors were designed and synthesised.</p><p><b>RESULTS</b>A novel series of compounds structurally related to arecoline have been prepared, the proposed structures of eighteen new compounds were established by IR, 1H NMR, MS spectroscopy and elemental analysis. The effects of the target compounds on the vasodilation activity were tested in the isolated preparation of mice thoratic aorta.</p><p><b>CONCLUSION</b>This preliminary pharmacological tests showed that the candidates have good vasodilation activities and were worthy to be intensively studied.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta, Thoracic
/
Pharmacology
/
Arecoline
/
Vasodilation
/
Vasodilator Agents
/
In Vitro Techniques
/
Chemistry
/
Nitric Oxide Donors
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2006
Type:
Article
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