Experimental study on animal with automatic drug injection based on predictive control for vascular interventional therapy / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 460-464, 2012.
Article
in Zh
| WPRIM
| ID: wpr-271752
Responsible library:
WPRO
ABSTRACT
This paper focuses on the animal experiment of automatic drug delivery based on predictive control for vascular interventional therapy. Improvement of drug delivery system based on predictive control used in simulated experiments was put forward after the presence of time varying parameters and the characteristics of individual differences of animal had been studied. The adaptability of time varying parameters and fault tolerance of the system were also enhanced. Different injection methods were tested on animals. It is proved that higher target blood concentration can be reached while injecting during diastolic than that while injecting during systolic or injecting at a constant speed within the whole cardiac cycle. The results also showed that the improved drug injection system based on predictive control which synchronizes with the cardiac cycle could be applied to clinical trials.
Full text:
1
Index:
WPRIM
Main subject:
Automation
/
Swine
/
Algorithms
/
Infusion Pumps
/
Infusions, Intra-Arterial
/
Pharmaceutical Preparations
/
Dipyrone
/
Forecasting
/
Methods
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
Journal of Biomedical Engineering
Year:
2012
Type:
Article