Effect of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 72-76, 2010.
Article
in English
| WPRIM
| ID: wpr-272945
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect and clinical significance of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma.</p><p><b>METHODS</b>Thirty-three patients with severe trauma were randomly divided into a control group (n=16) and a treatment group (n=17). The patients of two groups were all treated conventionally, and the only difference was that Xuebijing injection was given to patients of the treatment group. The CD4+ and CD8+ subpopulations of T-lymphocyte in the peripheral blood were detected respectively on admission, 3rd and 5th days after trauma by double antibody labeling and flow cytometry.</p><p><b>RESULTS</b>The CD4+ T-lymphocytes and CD4+/CD8+ ratio of peripheral blood in patients with severe trauma decreased markedly on the 3rd and 5th days after trauma. Furthermore, compared with control group, the peripheral CD4+ T-lymphocytes and CD4+/CD8+ ratio of treatment group renewed obviously on the 5th day after trauma, and showed statistical differences (P<0.05).</p><p><b>CONCLUSION</b>In the treatment of patients with severe trauma, the early use of Xuebijing injection is effective in correcting disorder or suppression of T-lymphocyte subpopulations regulating network, and promoting a more balanced profile of immunologic function.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Wounds and Injuries
/
Drugs, Chinese Herbal
/
T-Lymphocyte Subsets
/
CD4-CD8 Ratio
/
Therapeutic Uses
/
Drug Therapy
/
Allergy and Immunology
/
Injections
Type of study:
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2010
Type:
Article
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