Statistical methodologies used in genome-wide association studies / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 400-404, 2011.
Article
in Zh
| WPRIM
| ID: wpr-273176
Responsible library:
WPRO
ABSTRACT
In lieu of large samples of cases and/or controls with hundreds of markers spreading throughout the human genome, researchers started to notice the dramatic increase of genome-wide association study (GWAS) for complex disorders, in the last 5 years. This paper highlights the statistical challenges in such huge-scale genetic studies, and introduces the analytical strategies and steps for handling GWAS data. Such issues as quality control of data, population stratification, methods available to data analysis and results presentation, replication, as well as the limitations of GWAS studies and the challenges presenting for statistics, are addressed.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Epidemiology
Year:
2011
Type:
Article