Expression and diagnostic significance of CD34 in brain tumors of patients with refractory epilepsy / 中华病理学杂志
Chinese Journal of Pathology
; (12): 151-155, 2010.
Article
in Zh
| WPRIM
| ID: wpr-273413
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the immunohistochemical expression and diagnostic significance of CD34 in brain tumors of patients with refractory epilepsy.</p><p><b>METHODS</b>Immunohistochemical study for CD34 was performed on formalin-fixed paraffin-embedded tissue blocks of 54 cases of brain tumors occurring in patients with refractory epilepsy. The tumor types included ganglioglioma (GG, number = 21), dysembryoplastic neuroepithelial tumor (DNT, number = 8), tumors/lesions which had the transitional features that between glioneuronal hamartia and mixed neuronal-glial tumor (number = 21) and pleomorphic xanthoastrocytoma (PXA, number = 4). Cases of glioblastoma (number = 4) and oligoastrocytoma (number = 5) were used as controls.</p><p><b>RESULTS</b>Twenty of the 21 cases of GG, 1 of the 8 cases of DNT, 16 of the 21 cases of tumors/lesions which had the transitional features and 3 of the 4 cases of PXA showed cytoplasmic and membranous positivity for CD34. The adjoining brain tissues in 9 of the 18 cases of GG, 6 of the 16 cases of tumors/lesions which had the transitional features and 1 of the 3 cases of PXA also expressed CD34. In contrast, only 1 case of glioblastoma showed membranous positivity for CD34.</p><p><b>CONCLUSIONS</b>CD34 preferred to staining for GG and PXA. Which represent a valuable tool for distinguishing GG, PXA and DNT, oligoastrocytoma, glioblastoma.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Astrocytoma
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General Surgery
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Brain Neoplasms
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Neoplasms, Neuroepithelial
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Ganglioglioma
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Glioblastoma
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Antigens, CD34
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Diagnosis, Differential
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Epilepsy
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Pathology
Year:
2010
Type:
Article