Correlation between cytochrome 3A4+894C>T P450 gene polymorphism and outcomes of coronary intervention in patients with acute coronary syndrome / 南方医科大学学报
Journal of Southern Medical University
; (12): 261-265, 2016.
Article
in Zh
| WPRIM
| ID: wpr-273777
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between plasma cytochrome P450 3A4 (CYP3A4) 894C>T gene polymorphism and the risk of recurrence of adverse cardiac events after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).</p><p><b>METHODS</b>A total of 275 patients with ACS received standard dual antiplatelet therapy and PCI. Platelet aggregation rate (PAR) was detected in each patient before and 7 days after administration of the anti-platelet drugs. Single nucleotide polymorphism of CYP3A4 gene 894C>T was detected with PCR and microarray technique. The number of coronary artery lesions was determined by PCI and the Gensini score was calculated. The patients were followed up for 3-12 months after discharge.</p><p><b>RESULTS</b>No significant difference was found in CYP3A4 gene polymorphism between patients with clopidogrel resistance (CR group) and those without CR (NCR group) (P>0.05). Multivariate logistic regression analysis showed that CYP3A4 gene 894C>T polymorphism was not correlated with CR in patients with ACS (OR 1.359, P>0.05). During the follow-up, the incidence of cardiovascular events was significantly higher in CR group than in NCR group (P<0.05), but this difference was not related to the mutation type of 894C>T locus of CYP3A4 gene.</p><p><b>CONCLUSION</b>The CYP3A4 gene 894C>T polymorphism is not associated with the effect of anti-platelet therapy and the risk of cardiovascular event in patients with ACS following PCI.</p>
Full text:
1
Index:
WPRIM
Main subject:
Platelet Function Tests
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Therapeutics
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Blood Platelets
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Ticlopidine
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Platelet Aggregation Inhibitors
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Platelet Aggregation
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Polymorphism, Single Nucleotide
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Therapeutic Uses
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Alleles
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Cytochrome P-450 CYP3A
Limits:
Humans
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2016
Type:
Article