Effect of Ikaros in B Cell Acute Lymphoblastic Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1194-1198, 2015.
Article
in Zh
| WPRIM
| ID: wpr-274067
Responsible library:
WPRO
ABSTRACT
The Ikaros - a DNA-binding zinc finger protein, acting as a regulator of chromatin remodeling and gene transcription, is crucial for regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Function-loss mutations of IKZF1, gene encoding Ikaros are frequent in B cell acute lymphoblastic leukemia (B-ALL) and are associated with a poor prognosis. This review briefly summarizes the available data regarding the structure and function of Ikaros, the role of Ikaros as a tumor suppressor in B-ALL, and its regulation mechanism.
Full text:
1
Index:
WPRIM
Main subject:
B-Lymphocytes
/
Cell Differentiation
/
Genes, Tumor Suppressor
/
Ikaros Transcription Factor
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Mutation
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2015
Type:
Article