A new monoterpenoid glucoside from the twigs of Chamaecyparis obtusa var. breviramea f. crippsii / 药学学报
Acta Pharmaceutica Sinica
; (12): 1179-1182, 2012.
Article
in Zh
| WPRIM
| ID: wpr-274681
Responsible library:
WPRO
ABSTRACT
To investigate the chemical constituents of Chamaecyparis obtusa var. breviramea f. crippsii, various column chromatography and spectroscopic methods were used for the isolation and elucidation of compounds. One new monoterpenoid glucoside, (4S)-4-isopropylcyclohex-l-enecarboxylic acid 4-O-beta-D-glucopyranoside (1), together with five known compounds, (4R)-p-menth-l-ene-7, 8-diol 7-O-beta-D-glucopyranoside (2), skimmin (3), 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2H-1-benzopyran-2-one (4), stigmast-4-en-3-one (5) and 1, 4-benzenedicarboxylic acid 1-butyl-4-(2-methylpropyl) ester (6) were isolated and identified from the twigs of this plant. All compounds were isolated from this plant for the first time. The methanol extract of this plant showed cytotoxicity on cancer cell lines A549, BGC-823, Du145 and MDA-MB-231 with IC50 values of 0.94, 1.07, 0.95 and 0.96 microg x mL(-1), respectively. Yet, compounds 1, 2 and 3 showed no cytotoxicity on cancer cell lines HeLa, BGC-823 and A549.
Full text:
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Index:
WPRIM
Main subject:
Pharmacology
/
Plants, Medicinal
/
Stigmasterol
/
Molecular Structure
/
Chemistry
/
Plant Stems
/
Plant Leaves
/
Coumarins
/
Chamaecyparis
/
Monoterpenes
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2012
Type:
Article