Risk assessment of renal dysfunction caused by occupational lead exposure / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 170-174, 2010.
Article
in Zh
| WPRIM
| ID: wpr-275711
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the risk of renal dysfunction caused by occupational lead exposure through epidemiological investigation.</p><p><b>METHODS</b>The workers in a battery factory were selected as the subjects for the exposure and effect assessment. The occupational environmental monitoring data was collected and used to calculate the total external dose of lead. The relationship between external dose and internal dose of lead was analyzed. The external dose, blood lead (BPb) and urinary lead (UPb) were used as exposure biomarkers while the urinary N-acetyl-D-glucosaminidase (UNAG), and urinary albumin (UALB) were used as the effect biomarkers for the renal dysfunction caused by lead. Software of BMDS (BMDS 11311) was used to calculate BMD.</p><p><b>RESULTS</b>The external and internal does of lead was positively correlated (BPb r = 0.466, P < 0.01; UPb r = 0.383, P < 0.01). The levels of BPb, UPb in exposure group (654.03 microg/L, 143.45 microg/g Cr) were significantly higher than those in the control group (57.12 microg/L, 7.20 microg/g Cr), so were UALB, UNAG; in addition, all of them presented significant dose-response relationship. The BPb BMD of UALB, UNAG were 607.76, 362.56 microg/L respectively and the UPb BMD of UALB, UNAG were 117.79, 78.79 microg/gCr respectively.</p><p><b>CONCLUSION</b>Occupational lead exposure can cause renal dysfunction, which presents dose-response relationship; the risk assessment of renal dysfunction caused by occupational lead exposure is performed by BMD calculation of BPb and UPb.</p>
Full text:
1
Index:
WPRIM
Main subject:
Urine
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Blood
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Biomarkers
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Environmental Monitoring
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Surveys and Questionnaires
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Occupational Exposure
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Risk Assessment
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Kidney
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Kidney Diseases
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Lead
Type of study:
Etiology_studies
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Risk_factors_studies
Limits:
Adolescent
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Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2010
Type:
Article