Reactivation of chronic hepatitis B infection related to imatinib mesylate therapy in patients with chronic myeloid leukemia: two cases report and literatures review / 中华血液学杂志
Chinese Journal of Hematology
; (12): 743-746, 2012.
Article
in Zh
| WPRIM
| ID: wpr-278321
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To probe the cause for triggering HBV reactivation and possible management of the chronic hepatitis B individuals received imatinib.</p><p><b>METHODS</b>This study presented two cases of transient hepatitis B virus (HBV) reactivation and hepatic dysfunction during oral imatinib for chronic myeloid leukemia (CML) and made a literatures review about the pathogenesis, possible prophylactic and therapeutic management of such chronic hepatitis B individuals receiving imatinib.</p><p><b>RESULTS</b>Two CML patients, without prior liver dysfunction but with chronic HBV infection, suffered from transient HBV reactivation occurred during oral imatinib. Both of them finally obtained good outcome following the additional oral nucleotide antiviral therapy.</p><p><b>CONCLUSION</b>It remained unclear whether imatinib induced the reactivation of HBV in patients with a latent HBV infection. From our study, all candidates receiving oral imatinib should be screened for HBsAg and anti-HBc antibodies prior to initiation of imatinib. Prophylactic antiviral therapy should be offered to HBV-infected individuals along with a close monitoring for signs of reactivation.</p>
Full text:
1
Index:
WPRIM
Main subject:
Physiology
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Piperazines
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Pyrimidines
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Virology
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Virus Activation
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Benzamides
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Hepatitis B virus
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Therapeutic Uses
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Drug Therapy
Limits:
Adult
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Hematology
Year:
2012
Type:
Article