Expression and significance of HGAL and LMO2 in follicular lymphoma / 中华病理学杂志
Chinese Journal of Pathology
; (12): 83-85, 2016.
Article
in Zh
| WPRIM
| ID: wpr-278559
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the diagnostic value of HGAL and LMO2 expression and compare with CD10 and bcl-6 in follicular lymphoma (FL).</p><p><b>METHODS</b>63 cases of FL were collected from Guangdong General Hospital. The expression of HGAL, LMO2, CD10 and bcl-6 was assessed by immunohistochemistry.</p><p><b>RESULTS</b>The expression rates of HGAL, LMO2, CD10 and bcl-6 were 98.4% (62/63), 82.5% (52/63), 82.5% (52/63) and 87.3% (55/63), respectively. The expression rate of HGAL was higher than those of LMO2, CD10 and bcl-6, but the differences were not significant (P>0.05). There was no significant difference in HGAL, LMO2 and bcl-6 expression among FL1, FL2 and FL3 cases. The CD10 expression rate of FL1-3A cases was significantly higher than that of FL3B cases(P<0.01).</p><p><b>CONCLUSIONS</b>HGAL and LMO2, especially HGAL, can be used in FL particularly high grade FL as useful germinal center marker.</p>
Full text:
1
Index:
WPRIM
Main subject:
Immunohistochemistry
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Neprilysin
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Biomarkers, Tumor
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Lymphoma, Follicular
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Proto-Oncogene Proteins
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Germinal Center
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Adaptor Proteins, Signal Transducing
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Proto-Oncogene Proteins c-bcl-6
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LIM Domain Proteins
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Metabolism
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Pathology
Year:
2016
Type:
Article