Cellular immune function and its clinical implications in 45 patients with multiple myeloma / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 1053-1057, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-278947
ABSTRACT
<p><b>OBJECTIVE</b>To investigate cellular immune function and its clinical significance in patients with multiple myeloma (MM).</p><p><b>METHODS</b>45 MM patients were divided into three groupsnewly diagnosed (n=18), stable stage (n=17) and relapsed/refractory (n=10). The frequencies of T cell subtypes, natural killer (NK) cells, dendritic cells (DC), helper T cells (including Th1 and Th2), regulatory T cells(Treg) and Th17 cells in peripheral blood were detected by flow cytometry. Serum concentrations of β2 microglobulin (β2-MG), lactate dehydrogenase (LDH) and hemoglobin (Hb) were also detected, respectively.</p><p><b>RESULTS</b>Compared with controls and stable stage group, the ratios of CD4+/CD8+, DC1/DC2, and Th1/Th2, the numbers of Treg and NK cells were significantly lower in newly diagnosed group. However, the ratio of IL-17A/Treg was significantly higher in newly diagnosed group (P<0.05). Compared with stable stage group, the ratios of CD4+/CD8+, DC1/DC2 and Th1/Th2 were significantly lower, and the ratio of IL-17A/Treg was significantly higher in relapsed/refractory group (P<0.05). In higher ISS stages, the ratios of CD4+/CD8+ and Th1/Th2 were significantly lower and the ratio of IL-17A/Treg was significantly higher (P<0.05). There were negative correlations between the ratios of CD4+/CD8+, DC1/DC2, Th1/Th2 and the levels of β2-MG and LDH, respectively (P<0.05). The ratio of IL-17A/Treg was positively correlated with the levels of β2-MG and LDH (P<0.05). They were no correlated with the level of Hb (P>0.05).</p><p><b>CONCLUSION</b>The abnormal ratios of CD4+/CD8+, DC1/DC2, Th1/Th2 and IL-17A/Treg were closely related with disease condition stages, treatment outcomes, progression and prognosis in MM patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dendritic Cells
/
T-Lymphocytes, Regulatory
/
T-Lymphocytes, Helper-Inducer
/
Interleukin-17
/
Flow Cytometry
/
Immunity, Cellular
/
Multiple Myeloma
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS