Effects of Naomaitai capsule on learning and memory and content of Ach in rat model produced by cerebral ischemia-reperfusion / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 459-462, 2005.
Article
in Zh
| WPRIM
| ID: wpr-279139
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of Naomaitai capsule on the learning and memory abilities and the content of acetylcholine(Ach) in the brain tissue of the model rat.</p><p><b>METHOD</b>One vascular dementia(VD) model was produced by occlusion of bilateral common carotid arteries in rats with following steps:
ischemia 20 minutes-reperfusion 10 minutes-ischemia 20 minutes. The learning and memory abilities were tested by water maze. The other VD model was formed by 4-vessel occlusion-reperfusion injury in rats. The time of right reflect recovery and the content of Ach in the brain tissue were determined.</p><p><b>RESULT</b>Naomaitai capsule can significantly improve the learning and memory abilities of the dementia rats( P < 0.05, P < 0.01), increase the content of Ach (P < 0.05, P < 0.01) and reduce the time of right reflect recovery(P < 0.01).</p><p><b>CONCLUSION</b>Naomaitai capsule can improve the learning and memory abilities by increasing the content of Ach of the VD rats.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Plants, Medicinal
/
Psychology
/
Brain Chemistry
/
Capsules
/
Drugs, Chinese Herbal
/
Reperfusion Injury
/
Acetylcholine
/
Brain Ischemia
/
Chemistry
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article