Progress in infection pathway and intracellular trafficking of adenovirus / 生物工程学报
Chinese Journal of Biotechnology
; (12): 864-874, 2014.
Article
in Zh
| WPRIM
| ID: wpr-279465
Responsible library:
WPRO
ABSTRACT
The research on intracellular trafficking of adenovirus has been described mainly through observations of subgroup C adenoviruses in transformed cell lines. The basic elements of the trafficking pathway include binding to receptors at the cell surface, internalization by endocytosis, lysis of the endosomal membrane, escape to the cytosol, intracellular trafficking along microtubules, nuclear pore docking, and viral genome translocation into the nucleus. More than 80% of the adenovirus genome is delivered to the nucleus in a highly efficient manner in approximately 1 h. However, exceptions to this trafficking pattern have been noted, including variations based on target cell type, cell physiology, and adenovirus serotype. This review summarizes mechanism of adenovirus infection pathway and intracellular trafficking, providinging a foundation for the development of clinical adenoviral vector.
Full text:
1
Index:
WPRIM
Main subject:
Physiology
/
Endosomes
/
Virology
/
Cell Membrane
/
Cell Nucleus
/
Adenoviridae
/
Cytoplasm
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Endocytosis
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Virus Internalization
/
Genetic Vectors
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Biotechnology
Year:
2014
Type:
Article