Effects of exogenous IL-10 on IL-6 and ICAM-1 expression in inflammatory gingival tissue / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 343-345, 2002.
Article
in Zh
| WPRIM
| ID: wpr-279615
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study aimed at investigating effects of exogenous interleukine-10 (IL-10) on IL-6 and intercellular adhesion molecular (ICAM-1) expression in inflamed gingival tissue.</p><p><b>METHODS</b>The expression of IL-6 and ICAM-1 was examined using immunohistochemical techniques. Inflammatory gingival tissue treated with IL-10 was taken as the experimental group and the same patient's inflammatory gingival tissue without treatment of IL-10 was included into the control group.</p><p><b>RESULTS</b>IL-6 expression was found mainly in monocytes, macrophages, lymphocytes, endotheliocytes and fibroblasts. The expression of ICAM-1 was found mainly in epithelial cells, monocot-macrophages, lymphocytes, endotheliocytes and fibroblasts. The immunohistochemical optical density (IOD) of the expression of IL-6 and ICAM-1 was detected by using Image-Proplus software, and the results showed that the expression in the experimental group differed significantly from that in the control group.</p><p><b>CONCLUSION</b>The exogenous IL-10 may down-regulate IL-6 and ICAM-1 expression in inflammatory gingival tissue.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
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Down-Regulation
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Interleukin-6
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Interleukin-10
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Intercellular Adhesion Molecule-1
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Genetics
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Gingiva
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Gingivitis
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Metabolism
Limits:
Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
West China Journal of Stomatology
Year:
2002
Type:
Article