Study on the mechanism of oocyte aneuploidy by spectral karyotyping / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To establish the method of detecting oocyte aneuploidy by spectral karyotyping (SKY).</p><p><b>METHODS</b>The unfertilized oocytes were fixed 1-2 days after oocyte retrieval. Spectral karyotyping was performed according to the protocol.</p><p><b>RESULTS</b>64% of oocytes were normal, 36% of oocytes were aneuploidy, of which 22% were due to nondisjunction and 14% unbalanced predivision.</p><p><b>CONCLUSION</b>SKY is an effective method for detecting oocyte aneuploidy. Both nondisjunction and unbalanced predivision are involved in oocyte aneuploidy formation.</p>