Assessment of the cardiotoxicity of recombinant human endostatin using myocardial biochemical markers in cancer patients / 南方医科大学学报
Journal of Southern Medical University
; (12): 930-932, 2008.
Article
in Zh
| WPRIM
| ID: wpr-280066
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the value of the myocardial biochemical markers including creatine kinase MB isoenzyme (CK-MB), cardiac isoform of Tropnin-T (cTnT) and N-termimal pro-brain natriuretic peptide (NT-proBNP) and electrocardiogram (ECG) in monitoring the cardiotoxicity of recombinant human endostatin (rh-endostatin) in cancer patients.</p><p><b>METHODS</b>Forty cancer patients were divided into two groups and received rh-endostatin in addition to chemotherapy (group A, n=24) or chemotherapy only (Group B, n=24). Serum CK-MB, cTnT levels and plasma NT-proBNP levels were measured and the ECG was recorded in all the patients before and after each of the two therapy cycles.</p><p><b>RESULTS</b>In group A, serum CK-MB, cTnT and plasma NT-proBNP levels were significantly increased after the treatment in comparison with the baseline levels (P<0.05), but such increment was not observed in group B (P>0.05). With comparable baseline levels of CK-MB, cTnT and NT-proBNP before the treatment (P>0.05), patients in group A showed significantly higher levels of the indices than those in group B after each therapy cycle (P<0.05). Increased ECG abnormality were observed after rh-endostatin treatment in Group A (P<0.05) at a rate significantly higher than that of Group B after the second treatment cycle (P<0.05).</p><p><b>CONCLUSION</b>Rh-endostatin has definite cardiotoxicity, and detection of the myocardial biochemical markers of CK-MB, cTnT and NT-proBNP may help predict the occurrence of cardiotoxicity.</p>
Full text:
1
Index:
WPRIM
Main subject:
Ovarian Neoplasms
/
Peptide Fragments
/
Blood
/
Recombinant Proteins
/
Biomarkers, Tumor
/
Carcinoma, Non-Small-Cell Lung
/
Risk Assessment
/
Troponin T
/
Natriuretic Peptide, Brain
/
Endostatins
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article