The entry of Epstein-Barr virus into B lymphocytes and epithelial cells during infection / 病毒学报
Chinese Journal of Virology
; (6): 476-482, 2014.
Article
in Zh
| WPRIM
| ID: wpr-280340
Responsible library:
WPRO
ABSTRACT
Epstein-Barr virus (EBV) is a human herpesvirus associated with important human diseases, including infectious mononucleosis syndrome, malignant lymphoma, and nasopharyngeal carcinoma. The mechanism of EBV entry into host cells remains a subject of intensive research. After decades of study, researchers have identified several key proteins and different patterns of EBV intrusion into host cells. The viral surface glycoproteins, gp350/220, gp42, gB, gH, and gL, are involved in interactions with the CR2 receptor on the surface of B lymphocytes during viral entry. However, the majority of epithelial cells lack CR2 receptor expression, which makes viral invasion much more complex than in B lymphocytes. Three different models have been proposed to explain how EBV enters epithelial cells (1) "transfer of infection", mediated by B lymphocytes or Langerhans cells; (2) EBV utilizes its own proteins during the process of fusion with the cell membrane; and (3) progeny virions arising from EBV-infected epithelial cells cross lateral membranes into adjacent epithelial cells. This review will discuss the relevant mechanism of viral entry into B lymphocytes and epithelial cells during EBV infection.
Full text:
1
Index:
WPRIM
Main subject:
Physiology
/
Viral Proteins
/
Virology
/
B-Lymphocytes
/
Herpesvirus 4, Human
/
Epstein-Barr Virus Infections
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Epithelial Cells
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Virus Internalization
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Genetics
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Metabolism
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Chinese Journal of Virology
Year:
2014
Type:
Article