Increased serum levels of C-reactive protein and matrix metalloproteinase-9 in obstructive sleep apnea syndrome / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1482-1486, 2007.
Article
in En
| WPRIM
| ID: wpr-280402
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Obstructive sleep apnea syndrome (OSAS), characterized by intermittent hypoxia/reoxygenation (IHR), has been identified as an independent risk factor for cardiovascular diseases (CVD). The CVD biomarkers associated with OSAS have not been thoroughly investigated.</p><p><b>METHODS</b>Fifty-one men with OSAS recently diagnosed by polysomnography were classified into two groups according to the severity of apnea moderate to severe OSAS group (n = 28) and mild OSAS group (n = 23). Twenty-five obese men, of comparable age and body mass index (BMI), without OSAS were chosen as control subjects. Serum metabolic variables, C-reactive protein (CRP) and matrix metalloproteinase-9 (MMP-9) were measured. Spearman correlation and regression analysis were performed.</p><p><b>RESULTS</b>Serum concentrations of CRP and MMP-9 were significantly higher in 51 OSAS patients than in 25 control subjects. Levels of CRP and MMP-9 were significantly higher in patients with moderate to severe OSAS than in patients with mild OSAS or in obese control subjects. A positive correlation was found between levels of CRP and MMP-9 in OSAS patients. Regression analysis showed that after adjusting for age and BMI, apnea/hypopnea index (AHI) significantly correlated with serum concentrations of CRP and MMP-9 in patients with OSAS.</p><p><b>CONCLUSIONS</b>AHI, mirroring the frequency of IHR, was a predictor of enhanced circulating CVD biomarkers MMP-9 and CRP. Our data support the theory that IHR contributes to the upregulation of the inflammatory factors in OSAS patients.</p>
Full text:
1
Index:
WPRIM
Main subject:
Blood
/
C-Reactive Protein
/
Cardiovascular Diseases
/
Sleep Apnea, Obstructive
/
Matrix Metalloproteinase 9
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
En
Journal:
Chinese Medical Journal
Year:
2007
Type:
Article