Identification of the isoform in type II receptor of transforming growth factor-beta in patients with acute leukemia and its clinical significance / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 221-224, 2006.
Article
in Zh
| WPRIM
| ID: wpr-280697
Responsible library:
WPRO
ABSTRACT
Recent research indicates that TGF-beta and type II receptor (TbetaR-II) play an important role in the pathogenesis of tumor. A high frequency of abnormalities in TbetaR-II has been demonstrated in various cancers. To identify the mutation of TbetaR-II in patients with acute leukemia, the bone marrow samples from 6 patients with acute leukemia and 11 normal individuals as control were detected by long-range RT-PCR. To detect a deletion in sequence of the TbetaR-IIgene, the PCR products were cloned to T vector and then sequenced. The results showed that there was existance of the isoform of TbetaR-II in 2 cases out of 6 patients with acute leukemia. These two patients had more poor prognosis than others. In conclusion, there was the isoform of TbetaR-II in partial patients with acute leukemia, and the isoform may be related with prognosis.
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
/
Molecular Sequence Data
/
Base Sequence
/
Leukemia, Myeloid, Acute
/
Signal Transduction
/
Transforming Growth Factor beta
/
Classification
/
Protein Serine-Threonine Kinases
/
Receptors, Transforming Growth Factor beta
/
Protein Isoforms
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2006
Type:
Article