Association between interleukin-1 alpha-889 C/T polymorphism and Alzheimer's disease in Chinese Han population / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To explore the possible association between interleukin-1 alpha-889C/T (IL-1 alpha-889 C/T) polymorphism and Alzheimer's disease (AD) in Chinese Han population.</p><p><b>METHODS</b>A total of 520 AD patients and 505 normal controls were enrolled. The polymorphism of IL-1 alpha-889C/T was detected with real-time polymerase chain reaction. Multiple logistic regression and chi square test were performed for statistical analysis.</p><p><b>RESULTS</b>The frequencies of C/C, C/T, and T/T genotypes were 70.96%, 25.77%, and 3.27%, respectively, among AD patients, and 80.59%, 18.22%, and 1.19%, respectively, among non-dementia controls. In multivariate analysis, T/T and C/T genotypes of IL-1 alpha-889, age > or =65 years, and female were risk factors for AD. Adjusted for the age and sex, T/T and C/T genotypes were still associated with AD. The odds ratio for AD were 3.57 and 1.74 for individuals with T/T and C/T genotypes compared with individuals with C/C genotype. P value was 0. 019 and 0. 001, respectively.</p><p><b>CONCLUSION</b>The IL-1 alpha-889 T/T and C/T genotypes are likely to be susceptible factors for the development of AD in Chinese Han population. The susceptibility genotype, female, and age > or =65 years are risk factors for AD.</p>