Association between interleukin-1 alpha-889 C/T polymorphism and Alzheimer's disease in Chinese Han population / 中国医学科学院学报
Zhongguo yi xue ke xue yuan xue bao
; Zhongguo yi xue ke xue yuan xue bao;(6): 186-190, 2006.
Article
in Zh
| WPRIM
| ID: wpr-281235
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the possible association between interleukin-1 alpha-889C/T (IL-1 alpha-889 C/T) polymorphism and Alzheimer's disease (AD) in Chinese Han population.</p><p><b>METHODS</b>A total of 520 AD patients and 505 normal controls were enrolled. The polymorphism of IL-1 alpha-889C/T was detected with real-time polymerase chain reaction. Multiple logistic regression and chi square test were performed for statistical analysis.</p><p><b>RESULTS</b>The frequencies of C/C, C/T, and T/T genotypes were 70.96%, 25.77%, and 3.27%, respectively, among AD patients, and 80.59%, 18.22%, and 1.19%, respectively, among non-dementia controls. In multivariate analysis, T/T and C/T genotypes of IL-1 alpha-889, age > or =65 years, and female were risk factors for AD. Adjusted for the age and sex, T/T and C/T genotypes were still associated with AD. The odds ratio for AD were 3.57 and 1.74 for individuals with T/T and C/T genotypes compared with individuals with C/C genotype. P value was 0. 019 and 0. 001, respectively.</p><p><b>CONCLUSION</b>The IL-1 alpha-889 T/T and C/T genotypes are likely to be susceptible factors for the development of AD in Chinese Han population. The susceptibility genotype, female, and age > or =65 years are risk factors for AD.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Case-Control Studies
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Sex Factors
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Polymerase Chain Reaction
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Risk Factors
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Age Factors
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Interleukin-1
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Genetic Predisposition to Disease
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Asian People
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Alzheimer Disease
Type of study:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limits:
Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Zhongguo yi xue ke xue yuan xue bao
Year:
2006
Type:
Article