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Clinical efficacy study on calming liver and restraining Yang formula in treating patients with mild or moderate degree of essential hypertension / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 776-781, 2010.
Article in Chinese | WPRIM | ID: wpr-281718
ABSTRACT
<p><b>OBJECTIVE</b>To observe the therapeutic effect of calming the liver and restraining the Yang formula in treating patients with mild or moderate degree of essential hypertension (syndrome of hyperactivity of liver-Yang), and to explore its mechanism in lowering blood pressure.</p><p><b>METHOD</b>The 348 patients with EH of stage I , II were randomly divided into two groups, the 174 patients in the treated group were treated with the calming the liver and restraining the Yang formula, and the 174 patients in the control group were treated with amlodipine. The treatment course for them all was 12 weeks. The related clincial symptoms score and quality of life score estimated before and after treatment at 4th week, 8th week and 12th week were observed. Before and after treatment, the ambulatory blood pressure (AMBP), heart rate, blood lipid, serum livels of high-sensitivity C-reactive protein (Hs-CRP), Angiotensin-II (Ang II) and calcitonin gene-related peptide (CGRP) were measured respectively in 40 patients of the treared group and 40 patients of the control group.</p><p><b>RESULT</b>After treatment, the treatment in the treated group showed an effect better than that in the control group in terms of nigh-time blood pressure reducing rate (P < 0.05). The reducing blood pressure variability and total effective rate in the treated group were no significant than that in the control group. In respect of reducing symptomatic scores on dizzy, soreness and weakness of the waist and knees, disturbed and dry and bitter of mouth, ameliorating quality of life score, decreasing the levels of heart rate, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol(HDL-C) in the treated group were showing marked improvement as compared with that in the control group (P < 0.05 or P < 0.1). The improvement in the level of Ang II , Hs-CRP and CGRP before treatment in two groups were more significant than that after treatment (P < 0.05). However There were no difference in after treatment between the treated group and the control group.</p><p><b>CONCLUSION</b>The calming the liver and restraining the Yang formula shows favorable efficacy in lowering blood pressure on the patients with mild or moderate degree of essential hypertension. It can reduce the clincial symptoms, improve the quality of life, regulate blood lipid metabolism. Its mechanism may be related to the functional relieving inflammatory reaction and inhibition the activity of renin-angiotensin-aldosterone system (RAAS).</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Anxiety / Triglycerides / Blood Pressure / Drugs, Chinese Herbal / Cholesterol / Amlodipine / Therapeutic Uses / Drug Therapy / Heart Rate / Hypertension Type of study: Diagnostic study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Anxiety / Triglycerides / Blood Pressure / Drugs, Chinese Herbal / Cholesterol / Amlodipine / Therapeutic Uses / Drug Therapy / Heart Rate / Hypertension Type of study: Diagnostic study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2010 Type: Article