Relationship between human herpesvirus 6 infection and oral squamous cell carcinoma / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 334-336, 2003.
Article
in Zh
| WPRIM
| ID: wpr-281790
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between human herpesvirus 6 (HHV-6) and oral squamous cell carcinoma.</p><p><b>METHODS</b>The serum anti-HHV-6 antibody titers from oral squamous cell carcinoma patients and control subjects were detected by indirect immunofluorescence assay. HHV-6 DNA in peripheral blood mononuclear cells from oral squamous cell carcinoma patients and control subjects was amplified by PCR with primers from sequence of HHV-6 and the specificity was confirmed by Southern-blot hybridization with an internal probe oligonucleotide. An immunohistochemical staining using rabbit anti-HHV-6 antibody was used to detect HHV-6 antigen in oral tumor tissues from oral squamous cell carcinoma patients.</p><p><b>RESULTS</b>Significantly higher proportion of patients with oral carcinoma (16/16) had IgG antibody to HHV-6 in sera compared with those (12/16) in control subjects, and geometric mean titer of these two groups was 1:118 and 1:64 respectively (P less than 0.05). The detectable rate of HHV-6 DNA in peripheral blood mononuclear cells for the above groups was 10/16 and 6/16 respectively (P less than 0.05). HHV-6 antigens were positive in 9 out of 12 oral tumor cases and in only 2 out of 8 pericancerous tissues the difference between these two groups was also significant (P less than 0.05).</p><p><b>CONCLUSION</b>These results demonstrated the frequent presence of HHV-6 in oral squamous cell carcinoma, therefore, HHV-6 possibly play a role in the pathogenesis of oral squamous cell carcinoma.</p>
Full text:
1
Index:
WPRIM
Main subject:
Virology
/
Blood
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DNA, Viral
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Immunoglobulin G
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Mouth Neoplasms
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Carcinoma, Squamous Cell
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Herpesvirus 6, Human
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Herpesviridae Infections
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Allergy and Immunology
/
Genetics
Limits:
Humans
/
Infant
Language:
Zh
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2003
Type:
Article