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Prognostic significance of monosomal karyotype in acute myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology ; (12): 286-290, 2015.
Article in Zh | WPRIM | ID: wpr-282050
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the prognostic significance of monosomal karyotype (MK) in patients with acute myeloid leukemia (AML).</p><p><b>METHODS</b>The clinical data of 498 AML patients were analyzed retrospectively.</p><p><b>RESULTS</b>Of the 498 patients, 233 (46.8%) cases had an abnormal karyotype. 42 patients fulfilled the criteria for MK, which were 8.4% of all cases and 18.0% of patients with abnormal karyotype, respectively. The most frequent autosomal monosomies were -7 and -17. 70 patients had complex karyotype (CK), in all patients and patients with abnormal karyotype accounted for 14.1% and 30.0%, respectively. Patients with MK were associated with significantly older (median age 62.5 vs 52 years, P=0.003), and lower HGB concentrations (62.5 vs 77 g/L, P=0.009) and lower WBC counts (7.0×10⁹/L vs 11.7×10⁹/L, P=0.008). Among MK cases, the most frequent chromosome abnormalities were complex karyotype, -7, -5, 7q-, and 5q-. In univariate analysis, MK patients had worse survival than those without MK (7.3 months vs 26.3 months, P<0.001). CK patients also had poorer outcomes than patients without CK (14.8 months vs 26.3 months, P<0.001). In CK patients, survival was worse in MK patients than patients without MK (7.4 months vs 19.2 months, P=0.007). By COX analysis, MK was an independent prognostic factor, beyond NCCN criteria and CK [HR=2.610 (1.632-4.175), P<0.001].</p><p><b>CONCLUSION</b>MK was an independent adverse prognostic factor in AML patients.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Prognosis / Leukemia, Myeloid, Acute / Retrospective Studies / Abnormal Karyotype / Karyotyping / Monosomy Type of study: Observational_studies / Prognostic_studies Limits: Humans Language: Zh Journal: Chinese Journal of Hematology Year: 2015 Type: Article
Full text: 1 Index: WPRIM Main subject: Prognosis / Leukemia, Myeloid, Acute / Retrospective Studies / Abnormal Karyotype / Karyotyping / Monosomy Type of study: Observational_studies / Prognostic_studies Limits: Humans Language: Zh Journal: Chinese Journal of Hematology Year: 2015 Type: Article