Studies on therapeutic effects of zhenzhu qishi wan on stroke and hypertension of SHRsp / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 557-559, 2003.
Article
in Zh
| WPRIM
| ID: wpr-282268
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ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Zhenzhu Qishi Wan on blood pressure(BP), body weight(BW), stroke and survival rate of stroke-prone spontaneously hypertension rats(SHRsp).</p><p><b>METHOD</b>8-week-old SHRsp was randomly divided into three groups: control group, Zhenzhu Qishi Wan prevention group and therapy group (n = 10). SHRsp of prevention group were treated with Zhenzhu Qishi Wan by ig 150 mg.kg-1 per day for 6 weeks, and therapy group were given the same treatment two weeks later. Behavior and stroke were observed everyday; BW were weighted every week; BP were estimated every 2 weeks. Time of the first cerebral seizure of SHRsp was recorded.</p><p><b>RESULT</b>Zhenzhu Qishi Wan had obvious preventive and therapeutic effect on genetic hypertension. The BP of prevention and therapy groups were significantly lower than that of control group (P < 0.05 [symbol: see text] P < 0.01). The drug ameliorated general behavior of SHRsp, BW of prevention group increased faster than that of control group(P < 0.05 or P < 0.01), and BW of therapy group were also heavier than that of control group at the age of 14 weeks(P < 0.05). When the experiment ended, 60% SHRsp of control group showed stroke and 20% of them were dead, while only 20% SHRsp in each of Zhenzhu Qishi Wan-treated groups showed stroke and none of them died.</p><p><b>CONCLUSION</b>Zhenzhu Qishi Wan had significant hypotensive effect, and some protective effect on the stroke caused by hypertension.</p>
Full text:
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Index:
WPRIM
Main subject:
Rats, Inbred SHR
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Blood Pressure
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Drugs, Chinese Herbal
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Materia Medica
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Random Allocation
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Stroke
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Therapeutic Uses
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Drug Combinations
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Drug Therapy
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Hypertension
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2003
Type:
Article