Comparison of two preparation methods applied in tanshinone II(A)-loaded PLGA nanoparticles / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 578-581, 2007.
Article
in Zh
| WPRIM
| ID: wpr-283431
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To optimize formulation of tanshinone II(A)-loaded PLGA nanoparticles and compare the difference of two methods in preparation and quality of nanoparticles.</p><p><b>METHOD</b>The two methods were nanoprecipitation method and emulsion-evaporation method. Single factor experiments and central composite design and response surface method were used to optimize the formulation of nanoparticles. The nanoparticles were characterized at size, morphology, entrapment efficiency, drug loading, drug recovery rate, crystallinity and drug release in vitro.</p><p><b>RESULT</b>The mean diameters were 225 nm and 183 nm, the entrapment efficiency were 95.49% and 87.99%, the drug loading were 2.03% and 0.16%, and the drug recovery rates were 38.42% and 17.59% respectively for nanoprecipitation method and emulsion-evaporation method.</p><p><b>CONCLUSION</b>Nanoprecipitation method was better than emulsion-evaporation method for preparation of tanshinone II(A)-loaded PLGA nanoparticles.</p>
Full text:
1
Index:
WPRIM
Main subject:
Particle Size
/
Phenanthrenes
/
Plants, Medicinal
/
Polyglycolic Acid
/
Polymers
/
Chemical Precipitation
/
Quality Control
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Volatilization
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Chemistry
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Technology, Pharmaceutical
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article