Studies on analgesic effects and sites of oxymatrine-carbenoxolone sodium complex / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 822-824, 2008.
Article
in Zh
| WPRIM
| ID: wpr-284381
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the analgesic effects and sites of oxymatrine-carbenoxolone sodium complex (OCSC).</p><p><b>METHOD</b>Adopting formalin test, warm water tail-flick test and intracerebroventricularly (icv) injection to observe the analgesic effects of OCSC in mice.</p><p><b>RESULT</b>Intraperitoneally injecting (ip) OCSC (75, 150 mg x kg(-1)) remarkedly inhibited the pain of mice in the formalin test and prolonged latent phases of tail-shrinking of mice, icy OCSC (1.875, 3.75, 7.5 mg x kg(-1)) significantly prolonged latent phases of tail-shrinking of mice, it had dose-dependent effect with concentration.</p><p><b>CONCLUSION</b>The result indicated that OCSC has obvious analgesic effects and its mechanism may be involved in central nervous system (CNS).</p>
Full text:
1
Index:
WPRIM
Main subject:
Pain
/
Pharmacology
/
Quinolizines
/
Carbenoxolone
/
Chemistry
/
Therapeutic Uses
/
Dose-Response Relationship, Drug
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Drug Therapy
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Alkaloids
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Analgesics
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Type:
Article