Small ubiquitin-like modifier protein-specific protease 1 and prostate cancer / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 36-38, 2009.
Article
in En
| WPRIM
| ID: wpr-284721
Responsible library:
WPRO
ABSTRACT
Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). There are six members of the human SENP family, and each SENP has different cellular locations and substrate specificities. However, the precise roles of SENPs in cellular processes have not been elucidated to date. This brief review will focus on recent advances pertaining to the identified targets of SENP1 and its potential role in prostate cancer.
Full text:
1
Index:
WPRIM
Main subject:
Endopeptidases
/
Physiology
/
Prostatic Neoplasms
/
Cysteine Endopeptidases
/
Signal Transduction
/
Receptors, Androgen
/
SUMO-1 Protein
/
Hypoxia-Inducible Factor 1, alpha Subunit
Type of study:
Prognostic_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Asian Journal of Andrology
Year:
2009
Type:
Article