Microfluidic cell culture array chip for drug screening assays / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 779-785, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-286642
ABSTRACT
We developed a novel microfluidic cell chip, which enabled drug delivery, fluid control and cell co-culture. The device consisted of an array of 6x6 cell culture chambers, a drug gradient generator and fluidic control valves. Micro-dam structures of the chambers were able to trap cells while loading and drug gradient network generated drug gradient of 6 different concentrations. Also we applied hydraulic valves to control the microfluid and simulate the microenvironment of cells. We had investigated the viability of co-culturing cells in the chip and the ability for drug screening. This microfluidic cell chip has the potential in cell-based research of high throughput drug screening.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Umbilical Veins
/
Biosensing Techniques
/
Cells, Cultured
/
Hepatocytes
/
Cell Biology
/
Endothelial Cells
/
Microfluidics
/
Microfluidic Analytical Techniques
/
Drug Evaluation, Preclinical
/
Methods
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2009
Type:
Article
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