Effect of Kanglaite injection oncyclooxygenase activity in lung carcinoma A549 cell / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1621-1633, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-287323
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Kanglaite injection on cyclooxygenase activity in lung carcinoma A549 cells.</p><p><b>METHODS</b>The expression of mRNA of COX-1 and COX-2 were measured by RT-PCR. The expression of COX-2 protein was measured by Western-blot.</p><p><b>RESULT</b>Kanglaite injection could selectively decreased COX-2 mRNA expression and protein expression while COX-1 mRNA expression was unchanged.</p><p><b>CONCLUSION</b>Kanglaite injection is selectively inhibitory agent of COX-2, and possess inhibitory effects on cyclooxygenase 2.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Seeds
/
Plant Oils
/
RNA, Messenger
/
Drugs, Chinese Herbal
/
Gene Expression Regulation, Neoplastic
/
Chemistry
/
Carcinoma, Non-Small-Cell Lung
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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