Effects of sapindoside on blood pressure and vasoactive substance in renovascular hypertension rat / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effects of sapindoside on blood pressure, Ang II, Ald, ET in the blood plasma and NO in the serum in renovascular hypertension rat.</p><p><b>METHOD</b>The 2K1C (2 kidney 1 clap) hypertensive model rats were used and drugs had been given by ig. for 5 weeks. The blood pressure was measured at the 1, 3, 7, 14, 21, 28, 35 day after drug. At the end of 5th weeks, the Ang II, Ald, ET in the blood plasma and NO in the serum were measured.</p><p><b>RESULT</b>Sapindoside (H, M and L) by ig. for 5 weeks could significantly lower the blood pressure, increase the levels of NO in the serum, reduce the concentration of Ang II, Ald, ET in the blood plasma.</p><p><b>CONCLUSION</b>Sapindoside plays an important role in decreasing the blood pressure of renovascular hypertension rat.</p>