Studies on chemical constituents of rhizomes of Ligusticum chuanxiong / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study chemical constitutents of the rhizomes of Ligusticum chuanxiong.</p><p><b>METHOD</b>The rhizomes of L. chuanxiong were extracted with water to afford a water extract which was participated between H2O and EtOAc, n-BuOH, successively. The compounds were isolatedand purified by column chromatography from the EtOAc fraction, and identified based on spectral analyses.</p><p><b>RESULT</b>Eleven compounds were isolated from the rhizomes of L. chuanxiong, and structures were characterized as (4S)-p-menth-1-ene4, 7-diol (1), aromadendrane-4alpha, 10beta-diol (2), aromadendrane-4beta, 10alpha-diol (3), aromadendrane-4beta, 10beta-diol (4), augustic acid (5), xiongterpene (6), pregnenolone (7), 3(R), 8(S), 9(Z)-falcarindiol (8), senkyunolide F (9), senkyunolide I (10), 4-hydroxyl-3-butylphthalide (11).</p><p><b>CONCLUSION</b>Compounds 1-5 were obtained from the rhizomes of L. chuanxiong for the first time.</p>