Decreasing toxicity and synergistic effects of intracellular and extracellular polysaccharides from Phellinus igniarius to tumor-bearing mice / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 847-852, 2012.
Article
in Zh
| WPRIM
| ID: wpr-288692
Responsible library:
WPRO
ABSTRACT
To study the toxicity-decreasing and synergistic effect of intracellular and extracellular polysaccharides from Phellinus igniarius on S180 mice. The PIP and PIE were extracted from the products of liquid submerged fermentation of P. igniarius. Transplanting S180 mice tumor models were established so as to observe the changes in tumor inhibiting rate, indexes of the spleen and thymus, body weight, peripheral blood cells and IFN-gamma levels when CTX was used alone and when used in combination with the PIP and PIE from P. igniarius. The results indicate that the PIP and PIE from P. igniarius can increase the activity of body immunity, attenuate the toxicity of CTX as well, and improve the anti-tumor effects.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Pharmacology
/
Polysaccharides
/
Sarcoma 180
/
Spleen
/
Thymus Gland
/
Basidiomycota
/
Blood
/
Body Weight
/
Plant Extracts
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article