Fibroblast growth factor 23 and bone mineralisation / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 8-13, 2015.
Article
in English
| WPRIM
| ID: wpr-290163
ABSTRACT
Fibroblast growth factor 23 (FGF23) is a hormone that is mainly secreted by osteocytes and osteoblasts in bone. The critical role of FGF23 in mineral ion homeostasis was first identified in human genetic and acquired rachitic diseases and has been further characterised in animal models. Recent studies have revealed that the levels of FGF23 increase significantly at the very early stages of chronic kidney disease (CKD) and may play a critical role in mineral ion disorders and bone metabolism in these patients. Our recent publications have also shown that FGF23 and its cofactor, Klotho, may play an independent role in directly regulating bone mineralisation instead of producing a systematic effect. In this review, we will discuss the new role of FGF23 in bone mineralisation and the pathophysiology of CKD-related bone disorders.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Calcification, Physiologic
/
Fibroblast Growth Factors
/
Glucuronidase
/
Metabolism
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
International Journal of Oral Science
Year:
2015
Type:
Article
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